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Both О± TEA and MОІCD disrupt cholesterol rich lipid microdomains, leading to suppression of crosstalk between mER О± and RTKs, reduction of total and phosphoprotein levels of RTKs HER 1 and HER 2, decreased levels of pAkt and pERK1 2, as well as decreased levels of estrogen receptor О± activity via downregulation of nuclear estrogen receptor О± nER О± phosphorylation mediated by Akt and ERK Ser 118 and Ser 167 <a href=http://prilig.sbs>priligy and cialis</a>